Endocrine Abstracts

Coexistence of different types of brain tumors is a very rare condition. We present a clinical case of PRL-secreting adenoma and germ cell tumor coexistence in 14-year-old adolescent. The patient was admitted to our Center with complaints of headache with nausea episodes, left-sided ptosis. Visual acuity was: visus OD=1.0; visus OS=0.6 Cyl -0.5 ax 70=1.0. Neuroimaging revealed supra-para(D,S) sellar mass 39×32×21 mm. Laboratory data revealed hypothyroidism, hypocorti...

Aim: The aim of this study was to evaluate metabolic abnormalities in young adults getting treatments of acute lymphoblastic leukemia (ALL) and brain tumors (BT) in their childhood.Methods: We examined 50 patients in two groups. The group-1: 18 ALL-survivors (nine women and nine men). All of them received cranial irradiation in dose up to 18 Gy and chemotherapy. In group-2: 32 BT-survivors (14 women and 18 men) were included. All patients received cranio...

Aim: The aim of this study was to examine the incidence of metabolic abnormalities in adults getting treatments of brain tumors (BT) and acute lymphoblastic leukemia (ALL) in their childhood or adolescence.Methods: patients were divided in two groups. In group 1: 31 BT survivors (13 women and 18 men) were included. All patients received craniospinal irradiation up to 36 Gy and boost to the tumor up to 55 Gy and chemotherapy. The group 2: 18 ALL survivors...

Medulloblastoma is the most common malignant brain tumor in childhood. Treatment of medulloblastoma includes surgery, radiation therapy and chemotherapy. Craniospinal radiation can cause adverse effects on the endocrine system, specifically on the hypothalamic-pituitary axis. Increasing survival rates of pediatric patients with brain tumors lead to increased concern regarding long-term quality of life, including the detection and correction of endocrine disorders. One of the m...

The glucagon stimulation test (GST) may be used as a good alternative to the insulin tolerance test (ITT) in the diagnosis of secondary adrenal insufficiency (SAI). The aim of the study was to compare the GST and ITT for diagnostic SAI, to define cortisol cut-off points and factors affecting the appearance of false positive results in young adults followed CSI.Subjects and Methods: A retrospective study of 28 patients (median age 19 [17; 23]) at least 2 ...

Children and adolescents treated for solid brain tumors with chemotherapy and craniospinal irradiation are at increased risk of metabolic changes development. Current follow-up guidelines for cancer survivors recommend to monitor fasting glucose and HbA1 levels for diabetes/impaired glucose tolerance screening in these patients. The aim of our study was to evaluate metabolic changes in children treated for medulloblastoma with oral glucose tolerance test (OGTT). We examined 63...